Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

Phase 4

Completed

• Conditions: Deep Extubation
• Interventions: Drug: Desflurane with remifentanil; Drug: Desflurane

• Registration Number: NCT01924871
• Lead Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Brief Summary

It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2013-08-12
• Study First Submitted QC: 2013-08-16
• Study First Posted: 2013-08-19
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Status Verified: 2014-04
• Results First Submitted: 2014-04-04
• Results First Submitted QC: 2014-04-04
• Last Update Submitted: 2014-04-04
• Results First Posted: 2014-05-07
• Last Update Posted: 2014-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Age 20-60
• patients undergoing elective surgery take more than an hour
• Under general anesthesia using an LMA
• ASA I,II

Exclusion Criteria

• Patients on CNS depressants
• Chronic opioid use
• Corticosteroid
• Pregnant patients
• Full stomach
• Morbidly obese (BMI >35kg/m2)
• Hepatitis B
• Hepatitis C
• Coronary artery disease
• Liver disease
• Renal disease
• Seizure disorder

Dropout criteria:

• Need for reintubation due to breath holding
• high ETCO2 during self ventilation (ETCO2>50)
• Surgeon or patient request

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane with remifentanil group	Desflurane with remifentanil	1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil
Desflurane group	Desflurane	1.5 MAC desflurane until extubation

Primary Outcome Measures

Name	Time	Method
Awakening Time	Participants will be followed from the time of extubation in operating room to the time of discharge from recovery room, an expected average of 1day.	The outcomes assessor will record from the time of extubation in operating room to the time of eye opening and mouth opening

Secondary Outcome Measures

Name	Time	Method
Success Rate & Complication Rate Including Cough	assessing the success rate of deep extubation without complication and the occurrance of cough from the completion of surgery to 5minute after extubation.	We will assess the success rate of deep extubation without complication and the occurrence of cough during emergence from general anesthesia.

Trial Locations

Locations (1)

Chung-Ang University Hospital; 🇰🇷 Seoul, Korea, Republic of