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Influence of different lipid emulsions on glucose uptake and mitochondrial function in healthy adults

Completed
Conditions
Diabetes, Insulin resitance and mitochondrial dysfunction
Registration Number
NL-OMON21580
Lead Sponsor
Department of Endocrinology and Metabolism, Academic Medical Center Amsterdam, the Netherlands.
Brief Summary

/A

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
10
Inclusion Criteria

1. Healthy male volunteer

2. Caucasian

Exclusion Criteria

1. Fasting blood glucose > 5,6 mmol/L or abnormal OGTT (2-hour value after oral ingestion of 75 g, glucose >7.8 mmol/l) Fasting insulin concentration >50 pmol/l

2. BMI> 25 and BMI< 20

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
- Peripheral glucose uptake (Rd) <br /><br>- Resting, adp-stimulated and uncoupled mitochondrial respiration rates
Secondary Outcome Measures
NameTimeMethod
-Skeletal muscle metabolites of plasma FFA, i.e. glycosphingolipids <br /><br>- Plasma concentrations of adiponectin, insulin, cortisol, glucagon, catecholamines<br>
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