NCT00132106Unknown不适用
The Effect of a-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
适应症
相关药物
试验速览
- 阶段
- 不适用
- 试验地点
- 2
- 主要终点
- change in glucose uptake
研究概览
简要总结
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart failure of at least New York Heart Association (NYHA) class II
- •Left ventricular ejection fraction (LVEF) <= 40%
- •Age 18-75 years
排除标准
- •Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)
- •Tricyclic antidepressants
- •Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)
- •Hospitalisation in 6 weeks prior to the study
- •Any change in medication in 6 weeks prior to the study
- •Unstable angina
- •Orthopnoea
- •Known chronic disease of the autonomic nervous system
- •Diabetes mellitus
- •Oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot
结局指标
主要结局
change in glucose uptake
次要结局
未报告次要终点
研究者
研究点 (2)
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