The Renin-Angiotensin System in Essential Hypertension
Not Applicable
Terminated
- Conditions
- Hypertension
- Registration Number
- NCT00141583
- Lead Sponsor
- St George's, University of London
- Brief Summary
Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- Essential Hypertension
- SBP 140-159 mmHg
- DBP 90-99 mmHg
Exclusion Criteria
- Intolerance of or allergy to ACE Inhibitors or ARBS
- Pregnant or Breastfeeding
- Pre-menopausal women
- Uncontrolled cardiac or renal failure
- Diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in BP Change in PRA and aldosterone
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL
🇬🇧London, United Kingdom