Evaluating dexamethasone vs dexmedetomidine in preventing nausea and vomiting in post-operative period in patients undergoing laparoscopic surgery under general aneasthesia.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/04/051958
• Lead Sponsor: Suchana Maji

Brief Summary

This study is a randomized,double blinded, parallel group, single centre trial evaluating and comparing the efficacy of intravenous dexmethasone and intravenous dexmedetomidine on incidence of post opearative nausea and vomiting in patients undergoing laproscopic surgeries under general anaesthesia. the primary outcome will be to evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately. secondary outcomes will be to compare and evaluate incidence of rescue antiemetic used with dexmedetomidine and dexamethasone,to compare and evaluate side effects of dexmedetomidine and dexamethasone,to compare and evaluate patient satisfaction with Post-opeartive Nausea and vomiting.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-04-24
• Study Start: 2023-08-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

Patients of ASA physical status I and II, both gender in the mentioned age group who will give written informed consent.

Exclusion Criteria

• Patients with ASA physical status III of greater.
• Severe cardiorespiratory,hepatic,renal,neurological or endocrinal disease.
• Bradycardia(Heart Rate<60bpm).
• Pregnant and lactating women.
• Obesity(BMI>30kg/m2).
• Diabetes mellitus.
• Patientswith known hypersensivity of drug allergies.
• Patients who had taken H2 antagonists,antiemetic or psychoactive medication.
• Nausea, retching,or vomiting within 48hours before surgery.
• History of Motion sickness.
• Patients who refuse to participate in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately.	Baseline | Before Administration Of Drug | After administration of Drug | During Intubation | After Intubation | 45 mins Intraoperatively | At the end of Surgery | 15 minutes postoperatively | 2 hours postoperatively | 6 hours postoperatively | 12 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
To compare and evaluate incidence of rescue antiemetic used with dexmedetomidine and dexamethasone.	To compare and evaluate side effects of dexmedetomidine and dexamethasone.

Trial Locations

Locations (1)

Subharti Medical College and Hospital; 🇮🇳 Meerut, UTTAR PRADESH, India

Subharti Medical College and Hospital

🇮🇳Meerut, UTTAR PRADESH, India

Suchana Maji

Principal investigator

9472212523

suchana.majinn@yahoo.co.in