Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery
Overview
- Phase
- Phase 4
- Intervention
- Ringer-lactate "SAD"
- Conditions
- Bloodloss
- Sponsor
- K. C. Rasmussen
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Effect of colloid versus crystalloid on laboratory coagulation.
- Last Updated
- 12 years ago
Overview
Brief Summary
In order to reduce bloodloss and need for transfusion to investigate the effect of colloid and crystalloid on coagulation assuming no difference between the groups.
Investigators
K. C. Rasmussen
MD, specialist in surgery and research fellow
Rigshospitalet, Denmark
Eligibility Criteria
Inclusion Criteria
- •Patient more than 18 years old
- •Indication for elective post-renal operation including cystectomy
- •Patient without anticoagulative, acetylsalicylic acid or NSAID treatment for the last 5 days.
Exclusion Criteria
- •Intracerebral bleeding, manifest cardiac insufficient, renal insufficient demanding dialysis, hepatic or coagulation diseases
- •Pregnant or nursing
- •Disturbance in electrolytes
- •Patient under committee
- •Patient joining another trial interfering the actual trial.
Arms & Interventions
crystalloid
Intervention: Ringer-lactate "SAD"
colloid
Intervention: HES 130/04
Outcomes
Primary Outcomes
Effect of colloid versus crystalloid on laboratory coagulation.
Time Frame: 5-7 hours
Coagulation is analysed in bloodsamples before, during (10 minutes post cystectomia), at the end of the operation and 2 hours later on. The bloodsamples are analysed by thromboelastography (5000 series TEG analyzer, Haemoscope Corporation, Niles IL, USA) besides the classic coagulation parametres: platelet count, INR, Fibrinogen, APTT, D-dimer and Haemoglobin, Amylase and Creatinin.
Secondary Outcomes
- Effect of colloid versus crystalloid on the amount of bloodloss(5-7 hours)