Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients

Terminated

• Conditions: Depressive Disorder, Major

• Registration Number: NCT02737540
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The main objective of this study is to confirm the existence of risky decision making in a non strategic situation (Iowa Gambling Task) and a deficit of decision making in social situations, linked to greater sensitivity to injustice (Ultimatum Game) and a lower level of trust (Trust Game) in elderly depressed patients with a history of suicide attempts in comparison with older depressed patients without a history of suicidal acts and healthy subjects.

Detailed Description

The secondary objectives are to confirm or explore the deficits of certain cognitive processes involved in potentially suicidal behavior in depressed elderly persons but that have been little or not studied to date. These include:

A. cognitive control and sensitivity to interference (Victoria Stroop test, incompatibility test, flexibility test, Go / No-Go);

B. Strategic recovery of semantic memory (verbal fluency test);

C. Working memory (TEA);

D. Insight related to depression (Mood Disorders Insight Scale);

E. Recognition of facial emotions;

F. Emotional regulation;

G. Negative attitudes;

H. Self-perception and;

I. Time perspectives.

Finally, patients will be contacted by telephone at month 6 to assess the occurrence of a suicidal act during this period and thus calculate the predictive ability of cognitive and psychological factors.

Study Timeline

• Study First Submitted: 2016-04-08
• Study First Submitted QC: 2016-04-08
• Study First Posted: 2016-04-14
• Study Start: 2017-08-16
• Primary Completion: 2020-08-01
• Study Completion: 2020-11-30
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-28
• Last Update Posted: 2021-02-01

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Trust Game	Days 1-7
Ultimatum Game	Days 1-7
Iowa Gambling Task	Days 1-7

Secondary Outcome Measures

Name	Time	Method
Incompatibility Test	Days 1-7
Go-NoGo	Days 1-7
Bristol Emotion Recognition Test	Days 1-7
Balanced Temporal Perspective Scale	Days 1-7
Working memory - TEA	Days 1-7
Mood Disorders Insight Scale	Days 1-7
Cognitive Emotion Regulation Questionnaire	Days 1-7
Questionnaire on negative attitudes towards problems	Days 1-7
Suicide attempt within 6 months of follow-up	Month 6
Stroop Victoria Test	Days 1-7
Flexibility test	Days 1-7
Verbal fluency test	Days 1-7
Future autobiographical fluency task	Days 1-7
Revised self-awareness scale, Self-reference task	Days 1-7

Trial Locations

Locations (2)

CHRU de Nîmes - Hôpital Universitaire Carémeau; 🇫🇷 Nîmes Cedex 09, France

Clinique Les Sophoras; 🇫🇷 Nîmes, France