ongitudinal analysis of the joint microstructure changes assesed by HR-pQCT in rheumatoid arthritis who are treated with CTLA4-Ig.
Not Applicable
- Conditions
- Rheumatoid Arthritis
- Registration Number
- JPRN-UMIN000024535
- Lead Sponsor
- Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
[1] A patient who is pregnant or may be pregnant [2] A patient who has following disease that may change the bone structure: A patients who has paralysis due to cerebral stroke, a patient who receives hemodialysis, a patient undergoing treatment for malignant tumor, a patient who takes a drug for osteoporosis or steroid orally [3] A patient who has been administered with a molecular target drug (TNF inhibitor, IL-6 inhibitor, tofacitinib) including abatacept [4] A patient who cannot keep his/her extremities still [5] A patient who is determined as inappropriate as a subject for other reasons by a principle investigator
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Volume changes after 12 months of bone erosion that is detected by High Resolution peripheral Quantitative CT (HR-pQCT) in the evaluation joint during CTLA4-Ig treamtne.
- Secondary Outcome Measures
Name Time Method -Changes of bone microstructure compared with baseline -Correlation of Bone microstructure changes and joint ultrasound findings,biomarker -Correlation of bone microstructure changes and bone mineral density -Correlation of bone microstructure changes and joint MRI,joint XP.