Characterization and localization of microstructural changes in brain tissue in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

Recruiting

• Conditions: neuropyschiatric syndroms; CNS involvement in SLE; Neuropsychiatric Systemic Lupus Erythematosus; 10003816

• Registration Number: NL-OMON39726
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Men and women of 18-65 years: NPSLE patients diagnosed in our outpatient clinic with diffuse neurological complaints, SLE patients without neuropsychiatric complaints and Healthy subjects, without cerebral or central nervous system disease, SLE or other chronic inflammation in the body. All volunteers should be competent to give a written informed consent.

Exclusion Criteria

-Younger than 18
-Pregnancy
-Routine MRI contraindication for 3T and 7T scanners: cardiac pacemaker and defibrillator, vascular clips of the cerebral vessels, nerve stimulators, intraorbital or intraocular metallic fragments, cochlear implants, ferromagnetic implants, hydrocephaluspump, intra-uterine device, iron wire behind the teeth, permanent make-up, piercings or other metal objects that cannot be removed (fillings are allowed) and claustrophobia.
- Severe physical restriction (completely wheelchair dependent)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the quantification and localization of<br /><br>microstructural changes in the brain tissue due to NPSLE observed through MRI<br /><br>tools.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameter is characterization of the mechanisms causing the<br /><br>microstructural changes. </p><br>