Functional and structural studies of the microcirculation and the endothelial glycocalyx as well as omics-analyzes for specific molecular signatures in patients with COVID-19, Long Covid and MIS-C/PIMS

Recruiting

• Conditions: 09.9GPOSTCOVID19ZUSTANDNICHTNHERBEZEICHNETU10.9GMULTISYSTEMISCHESENTZNDUNGSSYNDROMINVERBINDUNGMITCOVID19NICHTNHERBEZEICHNETCOVID19VIRUSNACHGEWIESEN; U07.1; U09.9; COVID-19, virus identified; Post COVID-19 condition, unspecified

• Registration Number: DRKS00029642
• Lead Sponsor: Klinikum der Universität München, Campus Großhadern

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients with the following criteria should be included:
- Patients with positive SARS-CoV-2 serology or diagnosis of an acute Covid-19 disease
- Patients diagnosed with PIMS/MIS-C
- Patients diagnosed with Long Covid

Healthy controls without SARS-CoV-2 infection should be included.

Exclusion Criteria

The exclusion criteria include the lack of consent to participate in the study and the revocation of consent.

The healthy control patients must be free of infection, and they must not have any underlying cardiovascular diseases, including all diseases that affect the cardiovascular system, e.g. diabetes mellitus, underlying oncological diseases and neuromuscular diseases.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We hope that the investigations will contribute to a better understanding of the pathogenesis of SARS-CoV-2, especially MIS-C/PIMS and Long Covid.

Secondary Outcome Measures

Name	Time	Method
Furthermore we hope to generate starting points for prevention, therapy and prognosis.