Explorations into the structural and molecular cerebral differences between tremor dominant and non-tremor Parkinson*s Disease

Completed

Conditions: Parkinson's disease
tremor
10028037

Registration Number: NL-OMON42970

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 25

Inclusion Criteria

- Idiopathic Parkinson*s disease according to UK brain bank criteria.
- Absence of a clear resting tremor of at least one arm (UPDRS tremor-score <= 0).
- Mild to moderate disease severity (Hoehn and Yahr 1-3).

Exclusion Criteria

- Neurological or psychiatric co-morbidity (e.g. stroke, depression).
- Severe head tremor or dyskinesias.
- Cognitive impairment (MMSE < 26).
- General MRI exclusion criteria (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia).
- Co-medication associated with elongated QT-time.
- Pregnancy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>(1) Structural integrity of brain stem nuclei (substantia nigra pars compacta,<br /><br>retrorubral area, locus coeruleus and raphe nuclei) using DTI and SWI; (2) GABA<br /><br>concentrations in the thalamus both OFF and ON dopaminergic therapy; (3)<br /><br>Cognitive performance on dopamine-dependent (go/nogo) and dopamine-independent<br /><br>(paired associative learning) behavioural task. (4) functional connectivity at<br /><br>rest, both OFF and ON dopaminergic therapy; </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Result of clinical assessment of cognitive function (MMSE, FAB).<br /><br>- Result of clinical assessment of parkinsonian symptom severity (TRS, UPDRS)<br /><br>before and after medication.</p><br>