Targeted ablation for ventricular tachycardia (VT)

Not Applicable

• Conditions: ventricular tachycardia; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12620000049976
• Lead Sponsor: Townsville Hospital and Health Service

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-22
• Last Update Posted: 10 August 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Patients will be over 18 years of age (not inclusive) and meet standard requirements for catheter ablation of VT. Patients will be eligible if they had had a myocardial infarction, had undergone placement of an implantable cardioverter defibrillator (ICD), and had >1 episode of sustained VT or ICD therapy during treatment with anti-arrhythmic drugs within the previous 6 months.

Exclusion Criteria

Patients with ventricular fibrillation, previous VT ablation, acute ischemia, non-ischemic cardiomyopathy, uncontrolled heart failure, left ventricular thrombus, mechanical prosthetic valves, severe peripheral vascular disease, disease process likely to limit survival to <1year, dementia or pregnancy will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient will be seen in clinic every 3 months and data from their ICDs will be downloaded to detect VT events at follow-up. The primary outcome of the study will be recurrent VT storm or intermittent VT within 6-months of the procedure. [Within 6 months of procedure]

Secondary Outcome Measures

Name	Time	Method
Acute success determined by non-inducibility of clinical VT tested by programmed ventricular stimulation with 3 extrastimuli until refractoriness from RV catheter at the end of ablation.[Within 6 months of procedure];Hospitalization for heart failure. An hospital admission will be adjudicated as heart failure based on findings in hospital records of worsening pulmonary or peripheral congestion, and requires augmentation of diuretic therapy or intravenous vasoactive agent. [Within 6 months of procedure];Hospitalization for VT. An hospital admission will be adjudicated as due to VT when as per hospital records patient is admitted with a primary diagnosis of VT.[Within 6 months of procedure]; Cardiovascular death. Death and its cause will be adjudicated using a combination of telephone follow-up, medical records and national death registry search.[Within 1 year of procedure]