nderstanding tissue mechanics, architecture and function using a gravitational magnetic resonance elastography transducer.

Not Applicable

• Conditions: Tissue mechanics in healthy adults.; Tissue architecture in healthy adults.; Tissue function in healthy adults.; Musculoskeletal - Normal musculoskeletal and cartilage development and function; Neurological - Studies of the normal brain and nervous system; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12621001688875
• Lead Sponsor: euroscience Research Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-10
• Last Update Posted: 10 June 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Inclusion criteria for participants taking part in this study includes:
1.Being an adult (male or female) over the age of 18 years.
2.Being in good health with no known history of nervous system, skeletal or muscular disease or injury.
3.Having no known medical conditions or implantation that would preclude them from undergoing MRI scanning.

Exclusion Criteria

Exclusion criteria for those who are not eligible to participate in the study includes:
1.People under the age of 18 years (tissue mechanical properties change throughout development)
2.Women who are pregnant (there are risks to the unborn foetus of undergoing MRI while pregnant).
3.People with medical conditions, devices or implantation that cannot be safely imaged using MRI (MRI is a critical tool in the study).
4.A history of MRI related claustrophobia (there is no direct benefit to the participant for participating in the study that would warrant their partaking).
5.People weighing over 140 kg (to comply with the safe working limit of the MR scanner).
6.If participating in the EMG study, allergic reactions to skin preparation solutions, conductive gels/creams or medical tape; or an extreme aversion to needles such as a history of fainting as a result of the insertion of needles.
7. People with a history of skin disease or injury to the site where the MR elastography transducer will be positioned (as the vibration applied through this site may aggravate this condition).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Any differences in the shear moduli of adipose tissue under physiological large deformation conditions assessed by MR scanning and the technique of MR elastography.<br><br>[ At the conclusion of the adipose tissue MR study.];Any differences between the shear moduli of skeletal muscle in directions parallel to the microstructural tissue axes under physiological large deformation conditions assessed by MR scanning and the technique of MR elastography.[ At the conclusion of the skeletal muscle MR and EMG study.];Any differences between the shear moduli of skeletal muscle in directions perpendicular to the microstructural tissue axes under physiological large deformation conditions assessed by MR scanning and the technique of MR elastography.[ At the conclusion of the skeletal muscle MR and EMG study.]