The identification of cell structure damage, micronutrients, and gene mutation in proton pump inhibitor long term users.
Not Applicable
Completed
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0001688
- Lead Sponsor
- Gachon University Gil Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
The patients taking of proton pump inhibitor for treatment of gastroduodenal ulcer or reflux esophagitis more than one year at present hospital.
Exclusion Criteria
1.Patients under 19 years of age or over 75 years of age
2.Patients taking the drug containing the cobalamin, folate or pyridoxine within last 4 weeks.
3.Patients taking the drug affecting the absorbtion or metabolism of folic acid and vitamin within last 6 months. (exam, methotrexate, oral contraceptive, etc.)
4.Patients with a history of gastrointestinal surgery
5.Patients associated with severe clinical disease
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In peripheral blood vitamin B12, B6, folic acid, homocysteine measurement, etc. ;Measuring the frequency of micronuclei in peripheral blood lymphocytes
- Secondary Outcome Measures
Name Time Method Gene acting on vitamin B12 and folic acid