Restrictive Versus Liberal Transfusion for Elective Major Surgery and Perioperative Outcomes: Mortality, Morbidity and Requirement of Postoperative Blood Transfusion
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Transfusion Related Complication
- Sponsor
- Leyla Kılınc
- Enrollment
- 892
- Locations
- 1
- Primary Endpoint
- Restrictive or Liberal transfusion
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Investigators aimed to compare the restrictive and liberal blood transfusion methods applied in major surgical operations performed in Anesthesiology and Reanimation Clinic and investigate their effects on postoperative transfusion needs, morbidity and mortality.
Detailed Description
The test subjects consisted of 892 patients, who belong to ASA (American society of Anesthesiology) I -IV groups, underwent elective major surgery between the 01/01/2016-31/12/2016, and are over the age of 18 years. The demographic data (Age, sex, ASA (American society of Anesthesiology) scors, surgery type) were also recorded. we evaluated the value of Hemoglobin, platelet, APTT (activated partial thromboplastin time), INR (international normalized ratio) preoperatively and postoperatively. In this study, restrictive and liberal blood transfusion groups were investigated.restrictive and liberal transfusion hemoglobin threshold value respectively before perioperative transfusion was 8 g / dL. were defined as restrictive blood transfusion group and perioperative transfusion was over 8 g / dL were defined as liberal blood transfusion group. Adverse events (tachycardia, hypotension, the value of lactate and metabolic acidosis). Postoperatively, the amount of postoperative transfusion unit, duration of hospital stay, requirement of intensive care unit and mortality rate.
Investigators
Leyla Kılınc
medical doctor, anesthesiology specialist
Sisli Hamidiye Etfal Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Over 18 years old patients,
- •ASA I-II-III-IV,
- •Major surgeries ( Intra-abdominal, intracranial, head and neck malignancy surgery, femur and vertebra surgery)
Exclusion Criteria
- •Emergency operation,
- •Cardiovascular surgery,
- •Under 18 years old patients
Outcomes
Primary Outcomes
Restrictive or Liberal transfusion
Time Frame: 52 weeks
It is determined how many units of RBC (red blood cell ) used during major operations at the hospital in liberal transfusion group or restrictive transfusion group.
Secondary Outcomes
- Postoperative transfusion requirement(52 Weeks)
- Postoperative Duration of Stay in Hospital of patients(52 Weeks)
- Mortality(52 weeks)
- The Need of ICU(52 Weeks)