A Clinical Trial to study the Combined Effect of Mahatriphla Ghrita with Ayurvedic Therapy patients with Adhimantha (primary open angle glaucoma)

Phase 1

Conditions: Health Condition 1: H401- Open-angle glaucoma

Registration Number: CTRI/2022/05/042635

Lead Sponsor: Patanjali Bhartiya Ayurvigyan evam Anusandhana Sansthana Haridwar

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. Age 30 To 70 years

2. Patients of either sex.

3. Patients of POAG having IOP < 21mmHg and IOP > 21 mmHg.

4. Visual acuity more than 6/60 and clear media.

5. Patients of POAG

Exclusion Criteria

1.Age below 30 years and above 70 years.

2. Visual acuity less than 6/60

3. Secondary and developmental Glaucoma including exfoliative glaucoma, pigmentary glaucoma,trauma-induced, inflammatory glaucoma, family history of glaucoma

4. Evidence of any anterior segment pathology like conjunctivitis, keratitis, or acute uveitis.

5. History of opaque ocular media (as in cataracts, corneal opacities, vitreous opacities).

6. Pregnant women

7.Any malignancy, uncontrolled diabetes, uncontrolled hypertension.

8.People who are already registered under some other ongoing medical research

9. Contraindicated for Nasya.

10.Contraindicated for Tarpana.

Contraindicated for Rakta-mokshana (jalaukavcharan)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SUBJECTIVE PARAMETER <br/ ><br>1.Blurred vision <br/ ><br>2.Frequent change of presbyopic glasses <br/ ><br>3.Delayed dark adaptation <br/ ><br>4.Visual field defect <br/ ><br>5.Headache <br/ ><br>Timepoint: for subjective parameter 1st and 90th day <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
OBJECTIVE PARAMETERS: - <br/ ><br>1.Visual Acuity using SnellenÃ¢â?¬â?¢s chart <br/ ><br>2.IOP using Schiotz or Applanation Tonometry corrected with CCT <br/ ><br>3.Direct and indirect ophthalmoscopic examination <br/ ><br>4.Automated Perimetry <br/ ><br>5. RNFL to evaluate optic disc, optic cup <br/ ><br>Timepoint: For objective parameters 1st and 90th day