Hyperglycemic Response and Steroid Administration After Surgery (DexGlySurgery)

Completed

• Conditions: Diabetes; Healthy
• Interventions: Drug: Steroid Drug

• Registration Number: NCT03390179
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The hyperglycemic response to surgery and the added effect of low-dose steroids (dexamethasone 4 to 8mg), and whether these differ in diabetics and nondiabetics remain unclear. Therefore, we prospectively evaluate the intraoperative and postoperative serum glucose concentrations in diabetics and nondiabetics that received intravenous steroid administration. This multicentre study include \> 250 patients.Primary endpoiunt was glucose concentration at H6 after surgery. Secondary endpoints were glucose concentration at H12 and at H24 and effect of anesthesia (regional anesthesia)

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-04
• Study First Submitted: 2017-12-28
• Study First Submitted QC: 2017-12-28
• Study First Posted: 2018-01-04
• Primary Completion: 2018-02-28
• Study Completion: 2018-02-28
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-04
• Last Update Posted: 2019-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• elective surgery under anesthesia

Exclusion Criteria

• < 50 kg
• emergency
• insulin therapy
• cardiac surgery
• refusal
• hyperglycemia> 2g/L

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
diabetes	Steroid Drug	Patient with non insulin diabetes
control	Steroid Drug	Patient without diabete

Primary Outcome Measures

Name	Time	Method
glucose concentration	6-8 hour

Secondary Outcome Measures

Name	Time	Method
glucose concentration	12 hour
glucose concentraion	24 hour

Trial Locations

Locations (1)

Cuvillon; 🇫🇷 Nîmes, Gard, France