Effect of different doses of steroid on respiratory distress syndrome in moderate to late preterm neonates born between 320-366 weeks of gestation: A randomized controlled trial

Phase 1

Completed

• Conditions: neonatal RDS; dexamethasone dosage

• Registration Number: TCTR20200729002
• Lead Sponsor: Faculty of Medicine, Siriraj Hospital

Brief Summary

5 mg. dexamethasone administration is not inferior than 6 mg. Hypoglycemia was more common finding and significant in 6 mg. group than 5 mg.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-29
• Study Completion: 2022-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 370

Inclusion Criteria

pregnant women with gestational age 32-36+6 weeks of gestation with preterm labour (including singleton and twins pregnancy) and decide to participate in the study

Exclusion Criteria

Pregnant women who have previously received steroid therapy before 32 weeks of gestation, pregnant women with gestational diabetes and have steroid resistance will beexcluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
neonatal respiratory distress syndrome (RDS) 0-48 hours after delivery observe respiration pattern of newborn

Secondary Outcome Measures

Name	Time	Method
maternal outcome 0-48 hours after delivery temperature, foul smell discharge