Effects of dexamethasone on blood glucose concentrations in patients undergoing elective surgery under spinal anesthesia: a randomized, controlled trial.

Phase 4

• Conditions: HyperglycemiaIncrease of blood glucosePostoperative nausea and vomiting; Dexamethasone; Postoperative nausea and vomiting; Blood glucose; Hyperglycemia; Spinal anesthesia

• Registration Number: TCTR20240606002
• Lead Sponsor: Rajavithi Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-06
• Last Update Posted: 19 August 2024
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patients who scheduled for elective surgery under spinal anesthesia, 2. Have no diabetes mellitus, 3. Baseline blood sugar < 125 mg/dl, 4. ASA physical status I-II, 5. Apfel score 2 or more

Exclusion Criteria

1. BMI<18.5 or > 40 kg/m2, 2. Steroid use within 30 days, 3. Allergy to study drugs, 4. Epilepsy, GI bleeding, gut obstruction, 5. Taking medications with extrapyramidal side effects, 6. Cirrhosis child B and C, 7. CKD stage 3-5 (GFR<60 ml/min), 8. Peptic ulcer, 9. Operation more than 4 hours, 10. Convert to general anesthesia, 11. Receive dextrose containing fluid is given during the study period, 12. Pregnancy, 13. Other contraindications of the study drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood glucose 0, 2, 4, 6 and 8 hours after the study drug Dextrostrip

Secondary Outcome Measures

Name	Time	Method
Incidence of hyperglycemia 0, 2, 4, 6 and 8 hours after the study drug Dextrostrip,Postoperative nausea and vomiting 0, 2, 4, 6 and 8 hours after the study drug PONV score