Dexamethasone effect on oral glucose tolerance test
Phase 1
- Conditions
- diabetes mellitus.Diabetes mellitusE10-E14
- Registration Number
- IRCT201111308258N1
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 98
Inclusion Criteria
20-65 years old individuals with first degree relative of diabetic patients
Exclusion criteria: Active peptic ulcer? active herpetic corneal ulcer? psychosis? positive pregnancy test? current use of oral contraceptives in women and thiazide or glucocorticoids use in any person
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma insulin in 0,30,60,120 minutes during OGTT. Timepoint: first day and second day. Method of measurement: pmol/l.;Plasma glucose in 0,30,60,120 minutes durig OGTT. Timepoint: first day and second day. Method of measurement: mmol/l.
- Secondary Outcome Measures
Name Time Method AUC(g)=Area under the curve of glucose. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i)= Area under the curve of insulin. Timepoint: first day and second day. Method of measurement: By related formulae.;AUC(i) / AUC(g). Timepoint: first day and second day. Method of measurement: By related formulae.;HOMA-IR index. Timepoint: first day and second day. Method of measurement: By related formula.;Homa-B index. Timepoint: first day and second day. Method of measurement: By related formulae.;Matsuda index. Timepoint: first day and second day. Method of measurement: By related formulae.;Insulinogenic index. Timepoint: first day and second day. Method of measurement: By related formulae.;Disposition index. Timepoint: first day and second day. Method of measurement: By related formulae.