Prognostic Impact of Molecular Classification in High-Risk Endometrial Cancer - A Retrospective Study in an Indian Cohort.

Project Title: Prognostic Impact of Molecular Classification in High-Risk Endometrial Cancer - A Retrospective Study in an Indian Cohort. Endometrial cancer is a common cancer in women. While most cases are detected early and have good outcomes, some are high-risk and can behave aggressively. Recent studies have shown that molecular features of the tumor (such as POLE mutation, MMR deficiency, and p53 abnormality) can predict prognosis better than traditional methods. This retrospective study will analyze data of about 250 patients with high-risk endometrial cancer treated at Tata Memorial Centre between September 2019 and September 2025. Archived FFPE (Formalin-Fixed, Paraffin-Embedded tissue) tumor samples will be tested for molecular classification, and outcomes will be correlated with these subtypes. No new samples will be collected, and all data will be anonymized. There are no risks to participants, and findings may contribute to improving cancer care in the future.