Application of ICG Fluorescence Cholangiography in Laparoscopic Living Donor Left Lateral Sectionectomy

Not Applicable

Completed

• Conditions: Living Donor Liver Transplantation
• Interventions: Procedure: indocyanine green (ICG) fluorescence cholangiography

• Registration Number: NCT05506020
• Lead Sponsor: Fudan University

Brief Summary

The purpose of this study was to assess the effects of indocyanine green (ICG) fluorescence cholangiography during laparoscopic left lateral sectionectomy (LLLS) on the occurrence of biliary complications in both donors and recipients in living donor liver transplantation (LDLT) and to explore the optimal dose and injection time of ICG.

Detailed Description

This was a retrospective cohort study. The purpose of this study was to assess the effects of indocyanine green (ICG) fluorescence cholangiography during LLLS on the occurrence of biliary complications in both donors and recipients. The optimal dose and injection time of ICG were also investigated. From October 2016 to May 2022, the clinical data of 85 donors who underwent LLLS and relevant recipients in the Department of General Surgery of Huashan Hospital were retrospectively analyzed. According to whether ICG fluorescence cholangiography was used, they were divided into a non-ICG group (n=46) and an ICG group (n=39). Biliary complications were observed and the optimal dose and injection time of ICG were explored.

Study Timeline

• Study Start: 2016-10
• Primary Completion: 2022-05
• Study Completion: 2022-07
• Status Verified: 2022-08
• Study First Submitted: 2022-08-16
• Study First Submitted QC: 2022-08-16
• Last Update Submitted: 2022-08-16
• Study First Posted: 2022-08-18
• Last Update Posted: 2022-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

1. From October 2016 to May 2022, donors and their corresponding recipients underwent laparoscopic donor liver acquisition surgery in the general surgery department of Huashan Hospital.
2. Donor age ≥ 18 years old, regardless of gender; The receptor is the corresponding receptor of the donor, and the age and sex of the receptor are unlimited.
3. The medical history is complete, which can meet the requirements of this study.
4. Volunteer to participate in this study.

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Exclusion Criteria

1. The medical history is incomplete, which cannot meet the requirements of this study.
2. The donor or recipient expressly refused to participate in this study.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ICG group	indocyanine green (ICG) fluorescence cholangiography	indocyanine green (ICG) fluorescence cholangiography

Primary Outcome Measures

Name	Time	Method
Biliary complications	two months after operation	bile leakage and biliary stenosis