ltra-high resolution imaging of the subcortex in major depressive disorder

Completed

• Conditions: clinical depression; major depression; 10027946

• Registration Number: NL-OMON45813
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Inclusion criteria patient sample;a) Primary diagnosis of major depression according to DSM-V criteria ;Inclusion criteria healthy control sample;b) No lifetime diagnosis of/treatment for depression or other psychopathology
c) Normal/subclinical scores on dimensional measures of psychopathology

Exclusion Criteria

a) Psychoses, mania, Tourette*s syndrome, obsessive-compulsive disorder
b) Major internal or neurologic disorder
c) Traumatic head injury
d) Current substance abuse or dependence requiring treatment
e) Evidence of acute suicidal risk requiring intervention
f) MRI contradictions such as metal implants en claustrophobia
g) Left-handedness
h) Pregnancy
i) Insufficient knowledge of Dutch language

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- MRI data on structural/functional properties of deep-lying subcortical brain<br /><br>regions<br /><br><br /><br>- Clinical phenotypes of depression<br /><br><br /><br>- (Epi)Genetic data on relevant neurotransmitter systems </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>na</p><br>