ltra-high field imaging of the cortico-striato-subthalamic functional and structural connectivity to improve deep brain stimulation surgery in Parkinson's disease patients

Completed

• Conditions: Parkinson's; Parkinson's disease; 10028037

• Registration Number: NL-OMON41696
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

For all groups:
1. Subjects must be mentally competent;For group 1 (PD patients scheduled for DBS surgery):
1. Patients suffering from Parkinson's disease who are eligible for deep brain stimulation surgery.;For group 2 (PD patients not scheduled for DBS surgery):
1. Diagnosis of idiopathic PD according to the UK Brain Bank Criteria
2. Excellent levodopa response
3. Disease course of > 3 years;For the healthy controls only:
1. Healthy volunteers with the same age and gender distribution as both patient populations.

Exclusion Criteria

For all groups:
1. Metallic prostheses or pacemaker in the subject's body or other contra indications for MRI.
2. Any neurological disease (other than PD).;For group 1 (PD patients scheduled for DBS surgery):
1. Any neurological or psychiatric disease other than PD.;For group 2 (PD patients not scheduled for DBS surgery)
1. Any neurological or psychiatric disease other than PD.;For healthy volunteers:
1. Any neurological or psychiatric disease.
2. The use of medication affecting the central nervous system.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint will be the structural and functional partition of the<br /><br>STN into its motor and non-motor regions in PD patients and healthy controls. </p><br>