ltra-high field fMRI of subcortical auditory structures in patients with tinnitus

Recruiting

Conditions: phantom sound perception
Tinnitus
10022396
10011305

Registration Number: NL-OMON40521

Lead Sponsor: Clinical Trail Center Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

The main inclusion criteria of the tinnitus group are unilateral (i.e. tinnitus is experienced at one side of the head/at one ear), chronic (i.e. longer present than 6 months) and subjective (not caused by an acoustic source inside the head) tinnitus. Age between 18 and 75 years and a written informed consent prior to study initiation.

Exclusion Criteria

Exclusion criteria are: Fletcher Index > 50 dB HL for both ears (i.e. mean of hearing loss in decibels for 1 kHz, 2 kHz en 4 kHz), difference in average hearing threshold of more than 10 dB between left and right ear (large differences will influence the intra-individual analysis), hyperacusis (i.e. oversensitivity of sound), phonophobia (i.e. a persistent, abnormal and unwarranted fear of sound), misophonia (i.e. dislike of certain sounds), neurological-, neurosurgical- and psychiatric history, use of dopaminergic drugs (since this medication greatly influence the fMRI scans), morbid obesitas (BMI > 35) since it cannot be guaranteed that these subjects will fit in the scanner, current treatment of tinnitus and implanted devices or other metal objects that are not suitable for MRI.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint will be the tonotopic map in auditory brainstem<br /><br>structures including the cochlear nucleus complex up to the inferior<br /><br>colliculus.</p><br>

Secondary Outcome Measures