ongitudinal ultra-high field imaging in Parkinson’s Disease: Tracking the disease course.
Recruiting
- Conditions
- Parkinson's Disease
- Registration Number
- NL-OMON23958
- Lead Sponsor
- In this project we work together with patients and their representatives, MHeNs School for Mental Health and Neuroscience, Maastricht University Medical Centre (MUMC+), BioBank Maastricht UMC+ and Scannexus.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 190
Inclusion Criteria
Participants are eligible for participation in this study if they meet the following criteria:
1) All patients have to be diagnosed with PD by a neurologist, within the last 3 years before inclusion.
2) A score of = 24 on the Montreal Cognitive Assessment (MoCA) at baseline.
3) Able to read and understand Dutch.
4) 18 years of age or older.
5) Providing written informed consent.
Exclusion Criteria
1) Subjects with contra-indications for a MRI scan, such as claustrophobia or subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves.
2) Advanced cognitive impairment (MoCA <24) or dementia according to the DSM V criteria at baseline.
3) Subjects with other neurodegenerative diseases.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -To determine early and subtle MRI changes in PD patients which distinguish them from the healthy population and to create a diagnostic tool for neurologists based on these differences.
- Secondary Outcome Measures
Name Time Method -To detect whether different clinical phenotypes of PD patients also show different imaging characteristics. <br>-To correlate MRI characteristics to clinical phenotype, genetic characteristics and progression of symptoms and thereby providing a prognostic tool for individual PD patients.