The role of imaging in Parkinson*s disease subtypes: a pilot study .
Withdrawn
- Conditions
- Parkinson's10028037
- Registration Number
- NL-OMON35081
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
PD patients must fulfill the United Kingdom Parkinson*s Disease Society Brain Bank criteria for idiopathic PD.
PD patients must be allocated to subtype 4 based on their clinical scores.
A minimum age of 18 years is required for both patients and control subjects.
Exclusion Criteria
Control subjects with a disease of the central nervous system.
Participants with a contraindication for MRI.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters of this study will include clinical and magnetic<br /><br>resonance imaging (MRI) parameters. Clinical data include important demographic<br /><br>and disease-related characteristics as well as measures for disease severity,<br /><br>and the important motor (motor functioning and motor complications) and<br /><br>non-motor domains (cognition, depression, psychotic symptoms, depression, sleep<br /><br>problems, and autonomic dysfunction). The combination of clinical scores<br /><br>allocates patients in one of the four subtypes, and in this study, only<br /><br>patients allocated in the most severe PD subtype 4 are participating. The MRI<br /><br>measures will include volumetric, diffusion, and functional MRI. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>