Structural and functional MRI in Parkinson*s disease and healthy carriers with GBA mutation, an exploratory study
Recruiting
- Conditions
- Parkinson's disease1002929910028037
- Registration Number
- NL-OMON49472
- Lead Sponsor
- Radboud Universiteit Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
-Subjects participating and consented in the Luxembourg Parkinson*s Study.
-Subjects of both genders with a full capacity of consent for MRI data
collection and analysis.
-The participants fall within one of the four targeted groups (Parkinson
patients and healthy controls with and without GBA gene mutation)
-Use of anti-parkinsonian medication (for PD patients)
• Age 18 years or older
Exclusion Criteria
-Subjects who are not consented participants in Luxembourg Parkinson*s Study.
-Refusal to sign the informed consent for MRI data collection and analysis.
-Contraindication for MRI data collection (metal implants, pacemakers, etc...)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Motor task-related brain activity as a function of genotype (with or without<br /><br>GBA mutations) and disease (with or without PD). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Reward task-related brain activity as a function of genotype (with or without<br /><br>GBA mutations) and disease (with or without PD).<br /><br><br /><br>Motor and reward task-related cerebral activity as a function of medication<br /><br>status in PD patients (ON vs. OFF medication).<br /><br><br /><br>Structural MRI measures as a function of genotype (with or without GBA<br /><br>mutations) and disease (with or without PD). </p><br>