Transcranial sonography in Parkinson*s Disease and Restless Legs Syndrome
- Conditions
- animarum tibiarumEkbom syndromerestless legs10028037
- Registration Number
- NL-OMON32740
- Lead Sponsor
- Medisch Centrum Haaglanden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion criteria PD patients with RLS
1.Fulfillment of the United Kingdom PD Society Brain Bank criteria for idiopathic PD.
2.Definite RLS in which all four revised minimal criteria of RLS are fulfilled based on an personal history taken by a RLS trained investigator/ doctor;Inclusion criteria PD without RLS
1.Fulfillment of the United Kingdom PD Society Brain Bank criteria for idiopathic PD.
2.Definite no diagnosis of RLS based on a personal history taken by a RLS trained investigator/ doctor
3.Age, sex , PD severity (Hoehn & Yahr and total levodopa-equivalent) matched to the PD patients with RLS;Inclusion criteria of RLS without PD
1.Definite RLS in which all four revised minimal criteria of RLS are fulfilled based on an personal history taken by a RLS trained investigator/ doctor
2.All secondary RLS patients are excluded besides iron deficiency related RLs
3.Age and sex matched to the PD patients;Inclusion criteria healthy controls
1. Definite no RLS or other known diseases
2. Age and sex matched to the RLS patients without PD
1.No temporal bone window to perform a qualitatively good transcranial sonography
2.Iron medication
3.Pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To determine the echogenicity of the substantia nigra, red nucleus and brain<br /><br>stem raphe in these four groups</p><br>
- Secondary Outcome Measures
Name Time Method <p>To determine the serum iron status in these four groups<br /><br>To determine the relation between echogenicity and iron status in the four<br /><br>groups</p><br>