Efficacy of intra-articular injection of a newly developed plasma rich in growth factors (PRGF) versus hyaluronic acid on pain and function of patients with knee osteoarthritis
Not Applicable
Recruiting
- Conditions
- Knee osteoarthritis.Osteoarthritis of knee
- Registration Number
- IRCT20130523013442N23
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age between 45-75 years
Symptomatic knee OA with the pain aggravated by weight bearing
Symptoms lasting for at least 6 months despite conservative treatment
Kellgren-Lawrance radiology scoring system scores ranging from 2-3
Exclusion Criteria
History of trauma , surgery or any invasive procedure in the affected joint during the past 6 months
Mal-alignment in lower limbs and abnormal blood count or impared coagulation test
Pregnant women
Patients who were under immunosuppressant treatments
Those with an underlying systemic arthropathy (secondary OA)
Patients been treated with angiotensin converting enzyme inhibitors (ACE I) and significant deficiency in glucose 6 - phosphate dehydrogenase (G6PD) level
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Knee Pain. Timepoint: Before intervention, 6 months & 12months after intervention. Method of measurement: Change of WOMAC questionnaire scores.
- Secondary Outcome Measures
Name Time Method