Eevaluation of tissue inflammation in relation to immediate loaded and delayed loaded dental implants
Phase 2
Completed
- Conditions
- Health Condition 1: null- partially edentulous patients with bilaterally missing mandibular posterior teeth
- Registration Number
- CTRI/2017/09/009668
- Lead Sponsor
- All India India Institute of Medical Sciences new delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1.Bilateral missing mandibular molars or premolars.
2.Sufficient available bone in term of quality and quantity for placement of dental implant.
3.Free from systemic diseases affecting gingival tissue and osseointegration.
4.Positive informed consent.
Exclusion Criteria
1.General contraindication to implant surgery
2.H/O smoking, alcohol, drug or tobacco abuse
3.Pregnancy
4. Presence of systemic diseases or hereditary disorders.
5.Implant insertion torque less than 35 Ncm
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To evaluate the level of MMP 8 and CTSK in perimplant crevicular fluid (PICF) at different time interval (2weeks, 3, 12 months) for immediate loaded implants. <br/ ><br>2. To evaluate the level of MMP 8 and CTSK in perimplant crevicular fluid (PICF) at different time interval (2weeks, 3, 12 months) for delayed loaded implants <br/ ><br>Timepoint: 2weeks, 3, 12 months
- Secondary Outcome Measures
Name Time Method 1.To compare the level of MMP 8 and CTSK in perimplant crevicular fluid (PICF) for immediate and delayed loaded implants at different time interval. <br/ ><br>2.To evaluate the soft tissue response for immediate loaded implant at different time interval. <br/ ><br>3.To evaluate the soft tissue response for delayed loaded implant at different time interval. <br/ ><br>4.To compare the soft tissue response seen with the two different prosthetic options. <br/ ><br>Timepoint: 2weeks, 3, 12 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How do MMP-8 and CTSK levels correlate with tissue inflammation in immediate vs. delayed loaded dental implants?
What is the comparative effectiveness of immediate vs. delayed loading on osseointegration in mandibular posterior implants?
Which inflammatory biomarkers predict successful osseointegration in partially edentulous patients with immediate loaded implants?
What adverse events are associated with immediate loading of dental implants in mandibular posterior regions compared to delayed loading?
Are other matrix metalloproteinases or cathepsins involved in implant inflammation besides MMP-8 and CTSK in mandibular posterior teeth?