Retrospective Study of Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients

Recruiting

• Conditions: Invasive Fungal Infections

• Registration Number: NCT06498310
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients. There is little recent data in heart transplantation, particularly on the incidence and risk factors of fungal infections. . It is therefore important to have recent data on incidence, risk and prognostic factors in order to improve the management of this severe complication.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-08
• Status Verified: 2024-07
• Study First Submitted: 2024-07-04
• Study First Submitted QC: 2024-07-04
• Last Update Submitted: 2024-07-04
• Study First Posted: 2024-07-12
• Last Update Posted: 2024-07-12
• Primary Completion: 2025-11
• Study Completion: 2025-11-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Adult patient ≥18 years old

• Heart transplant

• Invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022

• Proven or probable infection with filamentous fungi according to EORTC/MSGERC criteria (20):

  • Invasive aspergillosis
  • Mucormycosis
  • Fusarium wilt
  • Scedosporiosis
  • Other filamentous fungus infection

• Subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research.

Exclusion Criteria

• Patient having expressed his opposition to participating in the study
• Patient not having a liver transplant
• Subject under guardianship, curatorship or safeguard of justice.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify the incidence, risk factors and prognostic factors associated with invasive fungal infections caused by filamentous fungi in heart transplant patients.	Up to 2 years	1. Incidence: number of cases of invasive fungal infection compared to the number of heart transplant patients per year in the study centers; 2. Risk factors: Case-control study. Clinical, microbiological or radiological factors statistically associated with cases of invasive fungal infection compared to controls.; 3. Prognostic factors: Clinical, microbiological or radiological factors of invasive fungal infections associated with mortality at the 12th week.

Trial Locations

Locations (1)

Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France; 🇫🇷 Strasbourg, France