A study to analyse relationship between gut microbiome and different types of lung cancers

Recruiting

Conditions: Healthy volunteers not having EGFR activating lung cancer
Neoplasms,

Brief Summary: The study is a prospective observational study to analyze the relationship between gut microbiome and different types of lung cancers. This study involves three groups- Group 1 will comprise of smoker NSCLC patients, Group 2 will consist of non-smoker EGFR mutated NSCLC and Group 3 comprises of control patients (no cancer). 30g of stool sample of patients of different lung cancers and normal volunteers will be collected for RNA sequencing to check for various gut microbiota. A preliminary 25 patients will be included in each cohort. The expected outcome of the study is that different microbiota in different percentages in EGFR positive lung cancers will establish that diet forms a major contributing factor in non-smoking related lung cancers.

Recruitment & Eligibility

Inclusion Criteria

Patients who have lung cancer with EGFR activating mutations.

Exclusion Criteria

Patient who is not able to provide stool sample for analysis.

Primary Outcome Measures

Name	Time	Method
The different microbiota in different percentage present in EGFR positive lung cancers will establish that diet forms a major contributing factor in non-smoking related lung cancers.	The outcome will be assessed at 4 weeks for the duration of 1 year

Secondary Outcome Measures

Name	Time	Method
NA	NA

Locations (1): Bhaktivedanta Hospital and Research Institute
🇮🇳
Thane, MAHARASHTRA, India
Bhaktivedanta Hospital and Research Institute
🇮🇳Thane, MAHARASHTRA, India
Dr Vijaykumar Gawali
Principal investigator
9320199122
drvijaykumar.g@bhaktivedantahospital.com