Effects of One Exercise Training Session on Brain Insulin Responsiveness
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Insulin Resistance
- Sponsor
- University Hospital Tuebingen
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Cerebral response after intranasal insulin administration
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.
Detailed Description
Investigate one acute bout of exercise on the brain insulin responsiveness using functional magnetic resonance imaging in combination with intranasal insulin in healthy participants of normal-weight and overweight/obesity. Two single endurance exercise sessions with different intensities will be evaluated, namely moderate intensity continuous training (MICT) and high-intensity interval training (HIIT). This will be compared to a waiting control condition. In a cross-over design, investigators will compare cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT compared to a control condition without exercise. Cerebral response is defined as the cerebral blood flow and resting state functional connectivity in response to intranasal insulin. Secondary outcomes include changes in blood metabolites and proteins and changes in eating behavior.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI between ≥ 19.5 to 39 kg/m2-
- •Less than 150 min/week for moderate-intensity physical activity
- •Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults)
- •Written consent to participate in the study
- •Written consent to be informed about incidental findings
- •Exclusion Criteria
- •Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke
- •Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, ...)
- •Insufficient knowledge of the German language
- •Persons who cannot legally give consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Cerebral response after intranasal insulin administration
Time Frame: 1 hour after exercise or waiting control
The resting-state cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control)
Secondary Outcomes
- Task based brain activation after high-intensity-interval-training (HITT) or moderate intensity continuous training (MICT) compared to control condition(1 hour after exercise or waiting control)
- Subjective feeling of hunger and food craving(baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control)
- Changes in Blood-brain barrier integrity(1 hour after exercise or waiting control)
- Performance during cognitive tasks(1 hour after exercise or waiting control)
- Changes in exerkines from plasma samples(baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control)
- Change in incretins from plasma samples(baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control)