Evaluation of indicators of glycative stress and beauty for skin from ingestion of test food
- Conditions
- middle-aged female
- Registration Number
- JPRN-UMIN000025986
- Lead Sponsor
- TTC CO., LTD.
- Brief Summary
Plasma pentosidine and fasting blood glucose were significantly reduced in both groups between before and after 12 weeks of intake. Also, VISIA wrinkles (left and right) were significantly reduced in L group and HOMA-IR was significantly reduced in H group. And, plasma 3-deoxyglucosone was reduced in the L group, and plasma carboxymethyl lysine was reduced in the H group, in trend. In addition, significant decrease was recognized in 5 items of liver function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 24
Not provided
(1)smoking (2)less than five hours in mean sleep (3)routinely taking foods or medicines which may affect skin or blood glucose (4)BMI more than 30 (5)treatment or a history of serious disease or affecting a secretion of sex hormones (6)diseases which affect this study (7)expected to be developed the allergy symptoms on skin (8)donated > 200 mL of blood within 1 month or > 400 mL within 3 months prior to the study (9)eat or drink too much during this trial, or habit of eating out (10)treated cosmetic care on measured site (11)treated cosmetic care except for measuring sites, or hormonal therapy for one year (12)a facial, a wash-rag, lost hair on measuring sites for one month ago, or plans these actions (13)no habit of preventing sunburn (14)plan to have ultraviolet exposure within a month before the screening test (15)wash the body providing strong skin irritation (16)the skin chronic disease including atopic dermatitis (17)the wound or inflammatory disease affecting the measuring skin (18)trouble by rough skin around a menstruates (19)work for anti-glycation foods related companies, or persons who have family members working for such companies (20)employed on a pre-dawn shift or on night duty more than twice (21)planned to go overseas (22)possibilities for emerging allergy related to the study (23)judged as unsuitable for the study based on the results of clinical and physical examination on screening test (24)participated in other clinical study within the last one month prior to the current study or are planned to participate in other clinical study after informed consent for the current study (25)planned to become pregnant after informed consent for the current study or are pregnant or lactating (26)judged as unsuitable for the study based on the results of lifestyle questionnaire (27)judged as unsuitable for the study by the investigator for other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Skin AGEs accumulation, internal body AGEs, skin carboxymethyl lysine, carboxymethyl lysine, 3-deoxyglucosone, skin elasticity, skin color, skin image analysis by VISIA
- Secondary Outcome Measures
Name Time Method ipid metabolism, sugar metabolism, the Anti-Aging QOL Common Questionnaire, physical measurement, blood pressure