Antibiotics for acute bronchitis

Completed

• Conditions: Acute bronchitis; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12606000509561
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-12-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 574

Inclusion Criteria

1) presenting with an acute cough of less than 14 days, 2) at least one other symptom of a respiratory tract infection (sputum production, dyspnoea, wheeze, chest discomfort/pain), 3) at least one 'complicated' acute bronchitis sign (pulse rate >100, respiratory rate >25, oral temperature >38ºC, abnormal chest signs, age >55, confined to bed/very unwell, co-morbidity), 4) have read the patient information sheet and provided written consent, 5) able and willing to follow study requirements.

Exclusion Criteria

1) a concurrent chronic respiratory illness that requires ongoing treatment, 2) antibiotics in the previous 3 weeks, 3) immunocompromised, 4) allergic to amoxycillin, penicillin, cephalospirins or beta-lactams, 5) lactose intolerant, 6) community acquired pneumonia, 7) bordatella pertussis.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine if amoxycillin, compared to placebo, improves morbidity in adult patients with 'complicated' acute bronchitis in general practice [Comparisons at Baseline, Day 7, Day 14 and Day 28]

Secondary Outcome Measures

Name	Time	Method
Medication compliance[Day 1 - 6];Side effects[Day 1 - 28]