ACTRN12605000447651已完成3 期
A randomised, double-blind clinical trial comparing theeffectiveness of single dose oral prednisolone versus single dose oral dexamethasone in reducing the severity of croup in children presenting to the Emergency Department, as measured by changes in the Westley croup score.
Mater Childrens' Hospital Department of Paediatric Emergency Medicine0 个研究点目标入组 99 人开始时间: 2005年9月21日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 99
研究概览
简要总结
Both prednisolone 1mg/kg and low-dose dexamethasone (0.15mg/kg) were found not to differ in efficacy from the currently recommended 0.6mg/kg dexamethasone. The use of these corticosteroid regimens in treating patients with mild to moderate croup is thus supported.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 6 Months 至 6 Years（—）
- 性别
- All
入选标准
- •(1) Children aged 6 months to 6 years presenting to the ED with a croup syndrome, clinically defined by hoarseness, barking cough and stridor.(2) Westley croup score of 2 or greater(3) Parents available for phone follow-up 1 week after study enrolment.
排除标准
- •(1) Chronic respiratory disease (excluding asthma)(2) Severe croup (defined as Westley croup score of >/= 8)(3) Nebulised adrenaline prior to or on arrival to the ED(4) Steroids within the preceding week(5) Known allergy to steroids(6) Varicella or exposure to varicella within the previous 3 weeks(7) Known immunodeficiency.
研究者
相似试验
已完成
3 期
Evaluating the effect of adding dexamethasone to lidocaine in improving the quality of the upper extremity anesthesia through venous injection (Bier's Block) in orthopedic operationsIntravenous regional anesthesia.Injuries to the wrist and hand AND Injuries to the elbow and forearm(S60-S69)IRCT2016052928158N1Vice chancellor for research, Hormozgan University of Medical Sciences100
招募中
2 期
To evaluate the adjuvant potential of methotrexate in mucosal/ limited mucocutaneous pemphigus vulgarisCTRI/2018/07/015002PGIMER
招募中
1 期
Comparison of Prednisolone and Dexamethasone on D28 mortality in patients on oxygen therapy with CoViD-19Care of severe forms of CoViD-19 from the transitional phase and the onset of the inflammatory phase with corticosteroidsMedDRA version: 23.0Level: LLTClassification code 10084270Term: SARS-CoV-2 acute respiratory diseaseSystem Organ Class: 10021881 - Infections and infestationsMedDRA version: 23.0Level: LLTClassification code 10084272Term: SARS-CoV-2 infectionSystem Organ Class: 10021881 - Infections and infestationsMedDRA version: 23.0Level: PTClassification code 10084268Term: COVID-19System Organ Class: 10021881 - Infections and infestationsMedDRA version: 21.1Level: LLTClassification code 10042839Term: Syndrome respiratory distress adultSystem Organ Class: 100000004855MedDRA version: 23.1Level: LLTClassification code 10084401Term: COVID-19 respiratory infectionSystem Organ Class: 10021881 - Infections and infestationsEUCTR2020-005883-78-FRHospital Center rené Dubos
已完成
3 期
Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary DysplasiaBronchopulmonary DysplasiaNCT00004785National Center for Research Resources (NCRR)54
Unknown
3 期
Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19Covid19ARDSNCT04499313Chattogram General Hospital60