Comparison between single dose oral prednisolone and oral dexamethasone in the treatment of croup: a randomised, double-blind clinical trial.
- Conditions
- Croup (laryngotracheobronchitis)Respiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12605000447651
- Lead Sponsor
- Mater Childrens' Hospital Department of Paediatric Emergency Medicine
- Brief Summary
Both prednisolone 1mg/kg and low-dose dexamethasone (0.15mg/kg) were found not to differ in efficacy from the currently recommended 0.6mg/kg dexamethasone. The use of these corticosteroid regimens in treating patients with mild to moderate croup is thus supported.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 99
(1) Children aged 6 months to 6 years presenting to the ED with a croup syndrome, clinically defined by hoarseness, barking cough and stridor.(2) Westley croup score of 2 or greater(3) Parents available for phone follow-up 1 week after study enrolment.
(1) Chronic respiratory disease (excluding asthma)(2) Severe croup (defined as Westley croup score of >/= 8)(3) Nebulised adrenaline prior to or on arrival to the ED(4) Steroids within the preceding week(5) Known allergy to steroids(6) Varicella or exposure to varicella within the previous 3 weeks(7) Known immunodeficiency.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method