Effect of Expiratory Muscle Strength on Hospital Admission, Disease Severity and Quality of Life in Patients With Bronchiectasis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Respiratory Muscle Strength
Study Overview
Brief Summary
This study investigates the relationship between expiratory muscle strength and clinical outcomes such as disease severity, hospital admissions, and quality of life in individuals with bronchiectasis.
Detailed Description
This study aims to examine the relationship between expiratory muscle strength and clinical outcomes such as disease severity, hospital admission history, and quality of life in individuals with bronchiectasis. Effective coughing is a critical physiological reflex for airway clearance; however, the relationship between expiratory muscle strength and cough effectiveness in the bronchiectasis population has not been clearly established. Identifying expiratory muscle weakness as a potential contributor to increased symptom burden and impaired airway clearance may improve clinical understanding and support the development of targeted physiotherapy interventions. The findings of this study could serve as a foundation for future interventional research in pulmonary rehabilitation and respiratory muscle training for this population.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Having a diagnosis of non-cystic fibrosis bronchiectasis
- •Without an acute infection at the time of assessment (confirmed by medical history, serum C-reactive protein levels, chest X-ray and/or HRCT).
- •Being between 18 and 65 years of age
Exclusion Criteria
- •Myopathies
- •Stroke (Cerebrovascular accident - CVA)
- •Pregnancy
- •Unstable cardiac disease
Outcomes
Primary Outcomes
Respiratory Muscle Strength
Time Frame: Baseline
Respiratory muscle function will be assessed by measuring maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in the sitting position using a mouth pressure device (MEC PFT Systems Pocket-Spiro).
Secondary Outcomes
- Modified Medical Research Council Dyspnea Score(Baseline)
- Leicester Cough Questionnaire(Baseline)
- Bronchiectasis Severity Index(Baseline)
- Hospital Anxiety Depression Scale(Baseline)
- Fatigue severity scale(Baseline)
- Spirometric measurements (Forced vital capacity)(Baseline)
- Spirometric measurements (First second forced expiratory volume)(Baseline)
- Spirometric measurements (FEV1/FVC ratio)(Baseline)
Investigators
Nisanur Tutuş
Principal Investigator
Saglik Bilimleri Universitesi