Total Splenectomy vs Partial Splenectomy in Non-malignant Hemoglobinopathies : Study Comparing the Effectiveness

• Conditions: Splenectomy; Status

• Registration Number: NCT05184647
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Partial splenectomy or total splenectomy are the two surgical treatment of non-malignant hemoglobinoptahie. The aim of this treatment is to decrease transfusion. The main risk is infectious in total splenectomy, that's why partial splenectomy was suggest. But the efficiency of partial splenectomy decrease over time and a totalisation could be mandatory.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-12
• Study First Submitted: 2021-12-22
• Study First Submitted QC: 2021-12-22
• Last Update Submitted: 2021-12-22
• Study First Posted: 2022-01-11
• Last Update Posted: 2022-01-11
• Study Start: 2022-01-16
• Primary Completion: 2022-06-30
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compared the effectiveness with the number of transfusion	Day 1	Compared the effectiveness with the number of transfusion after the surgery between total and partial Febrile urinary tract infection was defined as a positive urine examination with a single bacteria with more than 10.5 cfu/mL and more than 10.4 leukocytes/ml associated with fever above 38.5°C and C-reactive protein (CRP) above 50 mg/

Secondary Outcome Measures

Name	Time	Method
number of totalisation in partial	Day 1	number of totalisation in partial
Number of infectious event in total and partial splenectomy	Day 1	Number of infectious event in total and partial splenectomy

Trial Locations

Locations (1)

University hospital of Montpellier; 🇫🇷 Montpellier, France