Haemodynamics, arterial stiffness and endothelial function in young prehypertensive subjects

• Conditions: high-normal blood pressure; prehypertension; 10057166

• Registration Number: NL-OMON32038
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

1. willing and able to participate in the study protocol
2. age 18-30 years
3. average blood pressure 130-139/85-89 mmHg
4. blood pressure healthy controls with optimal blood pressure: < 120/80 mmHg

Exclusion Criteria

1. history of cardiovascular disease
2. chronic use of prescribed medication
3. any disease requiring chronic treatment by a medical specialist
4. cardiac arrhythmia

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference between prehypertensive and normotensive subjects in<br /><br>augmentation index </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The difference between prehypertensive and normotensive subjects in:<br /><br>- Pulse wave velocity<br /><br>- Central aortic blood pressure<br /><br>- Systemic vascular resistance (SVR)<br /><br>- Vascular changes (AIx and SVR) after single stimulation with salbutamol and<br /><br>nitroglycerin<br /><br>- Endothelial function as assessed with endopat2000<br /><br><br /><br>- Correlation between these parameters</p><br>