Acute radiation-induced skin reactions following hypofractionated vs. conventional whole-breast radiotherapy in breast cancer patients
Not Applicable
- Conditions
- L58C50RadiodermatitisMalignant neoplasm of breast
- Registration Number
- DRKS00017763
- Lead Sponsor
- niversitätsklinikum BonnKlinik für Radiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 168
Inclusion Criteria
Breast-conserving surgery for breast cancer
An intended fractionation regimen of either 50 Gy in 25 fractions (conventional fractionation) or 40.05 Gy in 15 fractions (hypofractionation)
Exclusion Criteria
Different fractionation regimens
Metastatic disease
Neoadjuvant or concomitant chemotherapy Indication for regional nodal radiation treatment
Previous radiation to the ipsilateral breast wall Breast reconstruction
Mastectomy
Previous operations in the irradiation area (e.g. bypass, pacemaker, etc.)
Active dermatitis
Any preexisting chronic dermatological disorders Treatment with topical or oral corticosteroids
Tattoos in the irradiation area
Patient refusal to participate
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maximum radiation dermatitis severity as assessed by gradings corresponding to the CTCAE v4.03 criteria and technical skin color measurements
- Secondary Outcome Measures
Name Time Method Patient-reported symptoms