Integrated Care of Co-morbidities vs Standard Care After Acute Hypercapnic Respiratory Failure in the Intensive Care Unit: a Randomized Controlled Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acute Hypercapnic Respiratory Failure
- Sponsor
- CTU
- Enrollment
- 188
- Locations
- 3
- Primary Endpoint
- Hospital readmission
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
The study will assess the potential benefit of implementing a complex bundle of interventions to treat important - often unrecognized - comorbidities in patients surviving an episode of Acute Hypercapnic Respiratory Failure (AHRF). This study will also provide a comparative analysis of the costs and health consequences of two alternative strategies to inform decision making about healthcare. All interventions are individually evidence-based and seem sound to hypothesize that implementing such interventions might improve patient's outcome and reduce the financial burder of repeated hospitalization in AHRF survivors.
Investigators
CTU
Principal investigator
University Hospital, Geneva
Eligibility Criteria
Inclusion Criteria
- •Consent form signed
- •Acute hypercapnic respiratory failure defined as PaCO2 \> 6.3 kPa requiring invasive or non-invasive mechanical ventilation in the ICU
Exclusion Criteria
- •Age \< 18 years old
- •Known or suspected neuromuscular diseases
- •Pregnancy
- •Iatrogenic respiratory failure (i.e. drug overdose, AHRF after starting opiates or increasing opiates dose)
- •Life expectancy \< 3 months
- •Confusion or major psychiatric illness
- •Patient unable to be weaned from NIV
Outcomes
Primary Outcomes
Hospital readmission
Time Frame: 1-year observation
Hospital or ICU readmission
Secondary Outcomes
- Health Related Quality of Life(Measured at regular 3, 6 and 12 months visits following patient's hospital discharge)
- Cost-effectiveness(1-year observation)