Effect of Integrated Care Involving Peripheral Functional Magnetic Stimulation for Sarcopenia
- Conditions
- Sarcopenia
- Registration Number
- NCT06182020
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
The goal of this clinical randomized trial is to test whether an integrated care involving peripheral functional magnetic stimulation and nutritional supplement is beneficial in population with age-related sarcopenia, as compared to usual care.
- Detailed Description
We will recruit participants with sarcopenia or possible sarcopenia. The participants will be divided into 2 groups. One group, the "integrated care" group, will receive both the peripheral functional magnetic stimulation to both the upper and lower limbs and nutritional supplement for consecutive 8 weeks. The other group, the "usual care" group, will receive an educational digital versatile disc (DVD) and a handbook for exercise suggestions on sarcopenia. We will compare before and after the intervention about the body composition, handgrip strength, 5-time chair stand test, 6-meter walk, and blood test for C-reactive protein and other cytokines related to sarcopenia. The participant's nutritional condition, activity level, life quality will also be analyzed via questionnaires before and after the intervention.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Age from 65 to 90
- Can walk independently for over 15 minutes
- Diagnosed with possible sarcopenia or sarcopenia (by Asian Working Group for Sarcopenia: 2019 Consensus Update onSarcopenia Diagnosis and Treatment)
- Cognitive impairment
- History of cerebrovascular disease
- Deep vein thrombosis
- Malignancy under treatment
- Coagulopathy
- Serious orthopedic condition over limbs
- Inability to walk independently without assistive device
- Any other conditions not suggested to performance exercise
- Medical implants (e.g. pacemaker, defibrillator, deep brain nerve stimulation, infusion pump, etc.)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Handgrip strength Before the intervention, and 1-2 weeks after the 8-week intervention We use a dynamometer to measure the handgrip strength (kg)
5-time chair stand test Before the intervention, and 1-2 weeks after the 8-week intervention We measure the time of a subject to transfer from a seated to a standing position and back to sitting five times.
Body composition Before the intervention, and 1-2 weeks after the 8-week intervention We use dual energy x-ray absorptiometry to evaluate the muscle mass (kg/m2) in the subjects.
6-meter walk Before the intervention, and 1-2 weeks after the 8-week intervention We measure the time of a subject to walk with the usual speed straightly for 6 meters.
- Secondary Outcome Measures
Name Time Method Leg circumference Before the intervention, and 1-2 weeks after the 8-week intervention We measure the largest calf circumference with seated position with knee flexed in 90 degrees.
Nutritional status Before the intervention, and 1-2 weeks after the 8-week intervention We use the questionnaire Mini Nutritional Assessment to evaluate the subjects' nutritional status.
Cytokines related to sarcopenia Before the intervention, and 1-2 weeks after the 8-week intervention We will check the concentrations of cytokines including the c-reactive protein from our subjects.
Life quality Before the intervention, and 1-2 weeks after the 8-week intervention We use the EuroQol-5 dimensions (EQ-5D) and Taiwan Short Form-36 questionnaires to evaluate the subjects' health life quality.
Activity level Before the intervention, and 1-2 weeks after the 8-week intervention We use the International Physical Activity Questionnaire to evaluate the subjects' activity levels.
Trial Locations
- Locations (1)
National Taiwan University Hospital Bei-Hu Branch
🇨🇳Taipei, Taiwan
National Taiwan University Hospital Bei-Hu Branch🇨🇳Taipei, Taiwan