Arterial to End-Tidal Carbon Dioxide Difference During Pediatric Laparoscopic Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Correlation between the Arterial to end-tidal carbon dioxide
研究概览
简要总结
Studying the arterial to end-tidal carbon dioxide difference in children undergoing laparoscopic surgeries under different intra-abdominal pressures is of extreme importance. This is because both hyper and hypocarbia are detrimental in this vulnerable age group.
详细描述
Capnography provides a non-invasive estimate of arterial CO2 levels and allows clinicians to modify mechanical ventilation settings in order to maintain normocapnia. Normally, a positive gap between arterial CO2 and ETCO2 of approximately 0.5 kPa is assumed in a healthy patient and ventilation settings are adjusted accordingly. However, the correlation between PaCO2 and PetCO2 during laparoscopic surgery is inconsistent mainly due to inter- and intra-individual variability. Discrepancies between arterial carbon dioxide and End-tidal carbon dioxide measures have been demonstrated in ventilated children with cyanotic congenital heart disease , infants with respiratory failure and during visceral and urological laparoscopic surgery. Moreover, as the increase in PaCO2 is directly proportional to the level of intra-abdominal pressure (IAP) used, variations in the arterial to end-tidal carbon dioxide difference can be also expected with different levels of IAP used.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children with the following inclusion criteria;
- •Weight: 10-30 kg.
- •Age: 1-6 years.
- •Sex: both males and females.
- •ASA physical status: I, II.
- •Operation: elective laparoscopic surgeries that last more than 45 min.
排除标准
- •Patients will be excluded if they have;
- •Patients with any perioperative cardiovascular or respiratory event occurred which made the study intervention clinically unacceptable,
- •Patients with unsatisfactory preoperative peripheral arterial oxygen saturation,
- •Patients with unsatisfactory preoperative hemoglobin level, neurological or psychiatric disease,
- •Children with a BMI >95th percentile for age.
结局指标
主要结局
Correlation between the Arterial to end-tidal carbon dioxide
时间窗: Intraoperative
The arterial CO2 will be analysed from the blood gas and the endtidal carbon dioxide will be recorded from the capnography tracing.
次要结局
- PaCO2-ETCO2 Difference(Intraoperative)
- The noninvasive systolic and diastolic arterial blood pressure(intraoperative)
- Heart rate(Intraoperative)
研究者
Hala Saad Abdel-Ghaffar
principal investigator
Assiut University