In Patients with Cirrhosis Who Have Minimal Hepatic Encephalopathy, Is Chinese Herbal Medicine Formula Jieduhuayu Granules Effective in Improving Cognitive and Neurophysiological Functions?

ational Natural Science Foundation of China0 个研究点目标入组 80 人开始时间: 2014年2月24日最近更新: 2020年1月13日

试验速览

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•1. All patients diagnosed as having cirrhosis at the Department of Hepatology of the First Affiliated Hospital of Guangxi University of Chinese Medicine, were candidates for enrollment.
•2. Patients’ Child-Turcotte-Pugh (CTP) class were A or B.
•3. Two or more positive indicators of NCT-A, the DST, the MMSE and the event related potential P300.

•1. Overt HE or a history of overt HE;
•2. Patients’ Child-Turcotte-Pugh (CTP) class were C;
•3. Psychological or neurological disorders;
•4. History of recent (4 weeks) use of Tranquilizers or central nervous system depressants like psychotropic drugs or antiepileptics;
•5. History of recent (4 weeks) alcohol intake;
•6. Gastrointestinal bleeding, infection, or recent (2 weeks) use of antibiotics;
•7. Electrolyte imbalance due to the recent use (2weeks) of diuretics;
•8. Body temperature at 37.5 degrees celsius or higher;
•9. A history of shunt surgery or transjugular intrahepatic portosystemic shunt(TIPS) for portal hypertension;
•10. Renal impairment;
•11. Hepatocellular carcinoma;
•12. Severe diseases such as congestive heart failure, pulmonary disease;
•13. Inability to perform NCT-A tests and MMSE tests because of hearing impairs and/or poor vision.
•14. Illiterate or uncooperative patients.

发起方

ational Natural Science Foundation of China