iver transplantation in patients with CirrHosis and severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs (CHANCE) Study on behalf of the EASL-CLIF Consortium - CHANCE

European Foundation for the Study of Chronic Liver Failure0 sites0 target enrollmentStarted: TBDLast updated: January 9, 2023

Trial Snapshot

No summary available.

•1. Subjects with the diagnosis of liver cirrhosis
•2. subjects who have been hospitalized for acute decomposition of liver cirrhosis and referred to the transplant team
•3. Patients who have been informed and signed for informed consent

•1. Acute or subacute liver failure without underlying cirrhosis
•2. Patients with hepatocellular carcinoma outside Milan criteria or other active neoplasia
•3. Subjects listed for transplantation other than the liver or liver-kidney transplant
•4. Subjects with previous liver transplantation
•5. Vulnerable population
•6. Pregnant and/ or breastfeeding women
•Patients who cannot provide prior informed consent
•7. Patients and team not committed to providing intensive care if needed
•8. Patients with relevant comorbidities that could impact the prognosis:
•Subjects with very severe hepatopulmonary syndrome
•subjects with severe pulmonary disease obstructive lung disease
•subjects with chronic kidney disease requiring hemodialysis
•subjects with severe heart disease
•subjects with known infection with HIV
•subjects with neurological or psychiatric disorders

Sponsor

European Foundation for the Study of Chronic Liver Failure