Complete Clinical Response With MRI Split Scar Sign as a Predictor to Complete Pathologic Response After Neoadjuvant Chemoradiation in Rectal Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Rectum Cancer
- Sponsor
- Alexandria University
- Enrollment
- 20
- Primary Endpoint
- Complete pathologic response
- Last Updated
- 5 years ago
Overview
Brief Summary
Patients with middle or low rectal cancer who receive neoadjuvant chemoradiation and achieve complete clinical response while their pelvic MRI have split scar sign are included. Patients will have total mesorectal excision and pathologic complete response will be assessed
Detailed Description
Patients with middle or low rectal cancer who have T3-4 and/ or N+ will be included. Patients will receive neoadjuvant chemoradiation in the form of pelvic irradiation by 50.4 thousands grays together with radio sensitization by 5-FU or oxaliplatin, 8 months after completion of neoadjuvant chemoradiation patients will be assessed clinically and radiologically. Complete clinical response is diagnosed if clinically no tumor is felt or just small scar and no tumor appears in MRI. Of these patients who achieve complete clinical response we will pick up cases who have split scar sign in the pelvic MRI. Patients will have total mesorectal excision 8-11 weeks after completion of neoadjuvant chemoradiation and pathologic complete response will be assessed. Correlation will be done between preoperative clinical response and postoperative pathologic response
Investigators
Khaled Madbouly
Professor of Surgery
Alexandria University
Eligibility Criteria
Inclusion Criteria
- •middle and low rectal cancer
Exclusion Criteria
- •Distant metastasis
Outcomes
Primary Outcomes
Complete pathologic response
Time Frame: after surgical excision with follow up of an average of 1 year
disappearance of tumor from resected specimen