Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Rectal Neoplasms
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Enrollment
- 99
- Locations
- 1
- Primary Endpoint
- Complete response MRI criterion
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Rectal adenocarcinoma
- •Locally advanced
- •Neoadjuvant therapy
- •MRI restaging
- •Rectal surgery
- •Definitive anatomopathology study
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Complete response MRI criterion
Time Frame: Day 0: immediately after the procedure
We selected several objective MRI criterion among literature and compared them between the two groups.
Secondary Outcomes
- MRI accuracy(Day 0: immediately after the procedure)