Affective startle modulation during therapy in patients with depressio

Suspended

• Conditions: Major Depressive Disorder; F32; F33; Depressive episode; Recurrent depressive disorder

• Registration Number: DRKS00012537
• Lead Sponsor: niversität des SaarlandesKlinische Psychologie und Psychotherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with the primary diagnosis of Depressive disorder undergoing Cognitive-behavioural therapy;
Control group: matched healthy participants

Exclusion Criteria

• no long-term medication (exceptions: oral contraception or occasionally a painkilling tablet up to one week before the start of the study; patient group: prescribed psychiatric medication)
• no drug or substance abuse
• no noise sensitivity and/or hearing impairment like tinnitus

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Startle responses during visualization of pictures with different affective content measured through Electromyography (EMG). Emotional reaction to the presented material measured through electrodermal responses (EDA).<br><br>Three different acquisition points: 1) before beginning of therapy (during or directly after the probatory sessions), 2) after the 12th therapy session, 3) after the 24th therapy session. Acquisition of the control group runs in a parallel design (same time between acquisition points).

Secondary Outcome Measures

Name	Time	Method
Interview and questionnaires focusing on depression (SKID, BDI-II, BSI, DAS) and subjective ratings of the pictures (Visual analogue scale) at the above named 3 acquisition points